Paderborn vs Bayer Leverkusen Prediction and Betting Tips | October 29th 2025

Paderborn will host Bayer Leverkusen at the Home Deluxe Arena on Wednesday in the second round of the 2025-26 DFB Pokal campaign. The home side are enjoying a brilliant run of results in the German second tier at the moment but will take a break from their early promotion charge this week as they turn their attention to cup football.

They locked horns with Viktoria Koln in the opening round of the DFB Pokal back in August and won 3-1, with Adriano Grimaldi netting an early brace before Filip Bilbija sealed the win from the spot in the 36th minute.

Bayer Leverkusen have also impressed in their league assignments of late, most recently beating 10-man Freiburg 2-0 to shake off last week’s Champions League disappointment. They thrashed fourth-tier side Großaspach in their cup opener earlier in the campaign and will hope to reach similar heights on Wednesday.

The visitors enjoyed a deep run in the domestic cup last season but ultimately fell short in the semifinals, suffering a 2-1 defeat to Arminia Bielefeld and missing out on the chance to make consecutive appearances in the final.

Paderborn vs Bayer Leverkusen Head-to-Head and Key Numbers

There have been eight meetings between the two teams. Paderborn have won two of those games while Leverkusen have won five times with their remaining contest ending level.

The two teams last faced off in the 2023-24 DFB Pokal campaign with the visitors winning the last-16 clash 3-1.

The hosts have never recorded a competitive clean sheet in this fixture.

Leverkusen are two-time winners of the domestic cup (1992-93, 2023-24) and have finished as runners-up on another two occasions.

Paderborn vs Bayer Leverkusen Prediction

Paderborn are on a brilliant six-game winning streak and have lost just one of their nine competitive games this term. They are massive underdogs heading into the midweek clash but will rely heavily on their home advantage to perhaps force the game to penalties.

Die Werkself are undefeated in their last seven domestic outings, picking up five wins in that period. The sheer gulf in class and quality between the two teams coupled with Leverkusen's strong away form this season should see the visitors advance to the next round.

Prediction: Paderborn 1-2 Bayer Leverkusen

Paderborn vs Bayer Leverkusen Betting Tips

Tip 1 - Result: Leverkusen

Tip 2 - Goals - Over/under 2.5 - Over 2.5 goals (Four of the last five matches between the two teams have produced more than 2.5 goals)

Tip 3 - Both teams to score: YES (Both sides have found the back of the net in four of their last five matchups)

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